Ovarian Hyperstimulation Syndrome (OHSS): New Strategies of Prevention and Treatment

Epidemiology and prevention of ovarian hyperstimulation syndrome (OHSS): a review.

Ovarian hyperstimulation syndrome (OHSS) is a rare iatrogenic complication of ovarian stimulation occurring during the luteal phase or during early pregnancy. Fortunately, the reported prevalence of the severe form of OHSS is small, ranging from 0.5 to 5%. Nevertheless, as this is an iatrogenic complication of a non-vital treatment with a potentially fatal outcome, the syndrome remains a seriou...

Prevention and Treatment of Ovarian Hyperstimulation Syndrome

Prevention and treatment of ovarian hyperstimulation syndrome.

The ovarian hyperstimulation syndrome (OHSS) is a potentially fatal condition with a pathophysiology that is not clearly understood. A shift in fluid from the extravascular space occurs, thought to be induced by cytokines and/or vascular endothelial growth factor. Human chorionic gonadotrophin (hCG), exogenous or endogenous, seems to be the triggering mechanism, resulting in early and late deve...

Treatment of ovarian hyperstimulation syndrome: new insights.

Ovarian hyperstimulation syndrome is the most serious iatrogenic complication resulting from ovarian stimulation. Currently there is no clear evidence of absolute efficacy for most of standard preventive and curative methods. Recent studies indicate that human chorionic gonadotropin increases vascular endothelial growth factor, vascular endothelial cadherin and vascular permeability via endothe...

Prevention of Ovarian Hyperstimulation Syndrome

Ovarian hyperstimulation syndrome (OHSS) is rare but most serious complication of ovarian stimulation. Symptoms are mainly related to increased capillary permeability leading to extravasation of fluid into extravascular compartment. Disease pathophysiology is linked to hCG (human chorionic gonadotropin) which acts through angiogenic molecule vascular endothelial growth factor (VEGF). There is r...